# Alkaline ceramidase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21172627](https://www.wikidata.org/wiki/Q21172627)  
**Source**: https://4ort.xyz/entity/alkaline-ceramidase-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q5QJU3)
3. Q20641742
4. [Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5QJU3&geneProductId=UniProtKB:Q5QJU3)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3)
6. [Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3)
7. [Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3)
8. [Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3)
9. [Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3)
10. [Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3)
11. [Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5QJU3&geneProductId=UniProtKB:Q5QJU3)
12. [Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5QJU3&geneProductId=UniProtKB:Q5QJU3)
13. [Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3)
14. [Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3)
15. [Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5QJU3)
16. Ensembl Release 99