Aldo-keto reductase family 1 member B
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: sorbinil
additional property: PropertyValue
  property ID: P129
  value: tolrestat
additional property: PropertyValue
  property ID: P129
  value: zenarestat
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P15121
additional property: PropertyValue
  property ID: P361
  value: aldo/keto reductase
additional property: PropertyValue
  property ID: P361
  value: NADP-dependent oxidoreductase domain superfamily
additional property: PropertyValue
  property ID: P361
  value: NADP-dependent oxidoreductase domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Aldo/keto reductase, conserved site
additional property: PropertyValue
  property ID: P527
  value: NADP-dependent oxidoreductase domain
additional property: PropertyValue
  property ID: P637
  value: NP_001333071
additional property: PropertyValue
  property ID: P637
  value: NP_001619
additional property: PropertyValue
  property ID: P637
  value: XP_005250291
additional property: PropertyValue
  property ID: P638
  value: 2PDQ
additional property: PropertyValue
  property ID: P638
  value: 1IEI
additional property: PropertyValue
  property ID: P638
  value: 2ACQ
additional property: PropertyValue
  property ID: P680
  value: aldo-keto reductase (NADP) activity
additional property: PropertyValue
  property ID: P680
  value: electron transfer activity
additional property: PropertyValue
  property ID: P680
  value: oxidoreductase activity
additional property: PropertyValue
  property ID: P681
  value: mast cell granule
additional property: PropertyValue
  property ID: P681
  value: Schwann cell microvillus
additional property: PropertyValue
  property ID: P681
  value: Schmidt-Lanterman incisure
additional property: PropertyValue
  property ID: P682
  value: stress-activated protein kinase signaling cascade
additional property: PropertyValue
  property ID: P682
  value: cellular response to peptide
additional property: PropertyValue
  property ID: P682
  value: daunorubicin metabolic process
additional property: PropertyValue
  property ID: P702
  value: AKR1B1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000285930
additional property: PropertyValue
  property ID: P705
  value: ENSP00000413205
confidence:
  popularity graph score:
    score: 0.004
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 26
      unique citations norm: 0.01
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 26
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q1259458
    source count: 1
    confidence: 0.2
    value label: sorbinil
  P129:
    value: Q7814620
    source count: 1
    confidence: 0.2
    value label: tolrestat
  P129:
    value: Q15633958
    source count: 1
    confidence: 0.2
    value label: zenarestat
  P129:
    value: Q1259458
    source count: 1
    confidence: 0.2
    value label: sorbinil
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P15121
    source count: 1
    confidence: 0.2
  P361:
    value: Q24782718
    source count: 1
    confidence: 0.2
    value label: aldo/keto reductase
  P361:
    value: Q41797908
    source count: 1
    confidence: 0.2
    value label: NADP-dependent oxidoreductase domain superfamily
  P361:
    value: Q83132852
    source count: 1
    confidence: 0.2
    value label: NADP-dependent oxidoreductase domain, protein family
  P361:
    value: Q95353774
    source count: 1
    confidence: 0.2
    value label: Aldo/keto reductase, conserved site, protein family
  P527:
    value: Q24780440
    source count: 1
    confidence: 0.2
    value label: Aldo/keto reductase, conserved site
  P527:
    value: Q24721100
    source count: 1
    confidence: 0.2
    value label: NADP-dependent oxidoreductase domain
  P637:
    value: NP_001333071
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001619
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005250291
    source count: 1
    confidence: 0.2
  P637:
    value: XP_024302463
    source count: 1
    confidence: 0.2
  P638:
    value: 2PDQ
    source count: 1
    confidence: 0.2
  P638:
    value: 1IEI
    source count: 1
    confidence: 0.2
  P638:
    value: 2ACQ
    source count: 1
    confidence: 0.2

value: 2FZB
source count: 1
confidence: 0.2

value: 2IKH
source count: 1
confidence: 0.2

value: Q15330990
source count: 1
confidence: 0.2
value label: aldo-keto reductase (NADP) activity

value: Q14358476
source count: 1
confidence: 0.2
value label: electron transfer activity

value: Q14349613
source count: 2
confidence: 0.4
value label: oxidoreductase activity

value: Q21209284
source count: 1
confidence: 0.2
value label: glyceraldehyde oxidoreductase activity

value: Q21097414
source count: 5
confidence: 1.0
value label: alditol:NADP+ 1-oxidoreductase activity

value: Q14860783
source count: 1
confidence: 0.2
value label: mast cell granule

value: Q21159013
source count: 1
confidence: 0.2
value label: Schwann cell microvillus

value: Q1640852
source count: 1
confidence: 0.2
value label: Schmidt-Lanterman incisure

value: Q14817956
source count: 1
confidence: 0.2
value label: nucleoplasm

value: Q14906193
source count: 1
confidence: 0.2
value label: plasma membrane bounded cell projection cytoplasm

value: Q15331430
source count: 1
confidence: 0.2
value label: stress-activated protein kinase signaling cascade

value: Q21972857
source count: 1
confidence: 0.2
value label: cellular response to peptide

value: Q21097416
source count: 1
confidence: 0.2
value label: daunorubicin metabolic process

value: Q21097417
source count: 1
confidence: 0.2
value label: doxorubicin metabolic process

value: Q14878798
source count: 1
confidence: 0.2
value label: maternal process involved in female pregnancy

value: Q17824985
source count: 1
confidence: 0.2
value label: AKR1B1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000285930
source count: 1
confidence: 0.2

value: ENSP00000413205
source count: 1
confidence: 0.2

value: ENSP00000414399
source count: 1
confidence: 0.2

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress
stated in qid: Q24321454
retrieved: 2017-10-31

source: Cloning and expression of human aldose reductase
stated in qid: Q24311265
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2017-10-31

source: Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin
stated in qid: Q24299666
retrieved: 2019-04-08

source: Cloning and expression of human aldose reductase
stated in qid: Q24311265
retrieved: 2017-10-31

source: The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48
stated in qid: Q28115731
retrieved: 2017-10-31

source: Aldose reductase: model for a new paradigm of enzymic perfection in detoxification catalysts
stated in qid: Q28118745
retrieved: 2017-10-31

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress
stated in qid: Q24321454
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Aldose reductase: model for a new paradigm of enzymic perfection in detoxification catalysts
stated in qid: Q28118745
retrieved: 2019-04-08

source: The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48
stated in qid: Q28115731
retrieved: 2019-04-08

source: Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism
stated in qid: Q24530114
retrieved: 2019-04-08

source: Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
stated in qid: Q24313258
retrieved: 2017-10-31

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2017-10-31

source: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
stated in qid: Q24311780
retrieved: 2017-10-31

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2017-10-31

source: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
stated in qid: Q24311780
retrieved: 2019-04-08

source: Large-scale proteomics and phosphoproteomics of urinary exosomes
stated in qid: Q24321631
retrieved: 2019-04-08

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: IUPHAR/BPS Guide to PHARMACOLOGY
stated in qid: Q17091219
retrieved: 2016-08-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q22679043
domain: protein
level: standard
html url: https://4ort.xyz/entity/aldo-keto-reductase-family-1-member-b
markdown url: https://4ort.xyz/entity/aldo-keto-reductase-family-1-member-b.md
facts url summary: https://4ort.xyz/entity/aldo-keto-reductase-family-1-member-b/facts.json
facts url standard: https://4ort.xyz/entity/aldo-keto-reductase-family-1-member-b/facts.json
facts url full: https://4ort.xyz/entity/aldo-keto-reductase-family-1-member-b/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T06:09:50.062069Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:41.053956+00:00Z