Aldo-keto reductase family 1 member B
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P07943
additional property: PropertyValue
  property ID: P361
  value: aldo/keto reductase
additional property: PropertyValue
  property ID: P361
  value: NADP-dependent oxidoreductase domain superfamily
additional property: PropertyValue
  property ID: P361
  value: NADP-dependent oxidoreductase domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Aldo/keto reductase, conserved site
additional property: PropertyValue
  property ID: P527
  value: NADP-dependent oxidoreductase domain
additional property: PropertyValue
  property ID: P637
  value: NP_036630
additional property: PropertyValue
  property ID: P680
  value: alditol:NADP+ 1-oxidoreductase activity
additional property: PropertyValue
  property ID: P680
  value: alcohol dehydrogenase (NADP+) activity
additional property: PropertyValue
  property ID: P680
  value: oxidoreductase activity
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P682
  value: tissue homeostasis
additional property: PropertyValue
  property ID: P682
  value: renal water homeostasis
additional property: PropertyValue
  property ID: P682
  value: monosaccharide metabolic process
additional property: PropertyValue
  property ID: P702
  value: Akr1b1
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000012879
confidence:
  popularity graph score:
    score: 0.004
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 26
      unique citations norm: 0.01
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 26
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P07943
    source count: 1
    confidence: 0.2
  P361:
    value: Q24782718
    source count: 1
    confidence: 0.2
    value label: aldo/keto reductase
  P361:
    value: Q41797908
    source count: 1
    confidence: 0.2
    value label: NADP-dependent oxidoreductase domain superfamily
  P361:
    value: Q83132852
    source count: 1
    confidence: 0.2
    value label: NADP-dependent oxidoreductase domain, protein family
  P361:
    value: Q95353774
    source count: 1
    confidence: 0.2
    value label: Aldo/keto reductase, conserved site, protein family
  P527:
    value: Q24780440
    source count: 1
    confidence: 0.2
    value label: Aldo/keto reductase, conserved site
  P527:
    value: Q24721100
    source count: 1
    confidence: 0.2
    value label: NADP-dependent oxidoreductase domain
  P637:
    value: NP_036630
    source count: 1
    confidence: 0.2
  P680:
    value: Q21097414
    source count: 4
    confidence: 0.8
    value label: alditol:NADP+ 1-oxidoreductase activity
  P680:
    value: Q21097135
    source count: 1
    confidence: 0.2
    value label: alcohol dehydrogenase (NADP+) activity
  P680:
    value: Q14349613
    source count: 3
    confidence: 0.6
    value label: oxidoreductase activity
  P680:
    value: Q21209284
    source count: 1
    confidence: 0.2
    value label: glyceraldehyde oxidoreductase activity
  P680:
    value: Q21097168
    source count: 2
    confidence: 0.4
    value label: retinal dehydrogenase activity
  P681:
    value: Q1385443
    source count: 1
    confidence: 0.2
    value label: extracellular space
  P681:
    value: Q14817956
    source count: 1
    confidence: 0.2
    value label: nucleoplasm
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm
  P681:
    value: Q220599
    source count: 3
    confidence: 0.6
    value label: cytosol
  P681:
    value: Q14906193
    source count: 1
    confidence: 0.2
    value label: plasma membrane bounded cell projection cytoplasm
  P682:
    value: Q14873636
    source count: 1
    confidence: 0.2
    value label: tissue homeostasis
  P682:
    value: Q14904977
    source count: 1
    confidence: 0.2
    value label: renal water homeostasis
  P682:
    value: Q21130418
    source count: 1
    confidence: 0.2
    value label: monosaccharide metabolic process
  P682:
    value: Q21209283
    source count: 2
    confidence: 0.4
    value label: sorbitol biosynthetic process

value: Q14916296
source count: 1
confidence: 0.2
value label: response to water deprivation

value: Q24369426
source count: 1
confidence: 0.2
value label: Akr1b1

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000012879
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: In vitro expression of rat lens aldose reductase in Escherichia coli
stated in qid: Q28575307
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Effects of melatonin on plasma oxidative stress in rats with streptozotocin induced diabetes
stated in qid: Q29144147
retrieved: 2019-04-08

source: Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase
stated in qid: Q28206428
retrieved: 2019-04-08

source: Electron microscopic immunocytochemical evidence for the mechanism of blood-retinal barrier breakdown in galactosemic rats and its association with aldose reductase expression and inhibition
stated in qid: Q28566703
retrieved: 2019-04-08

source: Fine-structural localization of aldose reductase and ouabain-sensitive, K(+)-dependent p-nitro-phenylphosphatase in rat peripheral nerve
stated in qid: Q28570962
retrieved: 2019-04-08

source: Aldose reductase deficiency protects sugar-induced lens opacification in rats
stated in qid: Q28566633
retrieved: 2019-04-08

source: Characterization of aldose reductase and aldehyde reductase from the medulla of rat kidney
stated in qid: Q28575963
retrieved: 2019-04-08

source: Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects
stated in qid: Q28572164
retrieved: 2019-04-08

source: Aldose reductase and myo-inositol transporter mRNA are independently regulated in rat renal medulla
stated in qid: Q28570983
retrieved: 2019-04-08

source: Redox activation of aldose reductase in the ischemic heart
stated in qid: Q28564820
retrieved: 2019-04-08

source: Aldose reductase regulates TGF-beta1-induced production of fibronectin and type IV collagen in cultured rat mesangial cells
stated in qid: Q28566019
retrieved: 2019-04-08

source: Aldose reductase, a key enzyme in the oxidative deamination of norepinephrine in rats
stated in qid: Q28576086
retrieved: 2019-04-08

source: Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury
stated in qid: Q28571691
retrieved: 2019-04-08

source: Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth
stated in qid: Q28564219
retrieved: 2019-04-08

source: The purification and properties of aldose reductase from rat ovary
stated in qid: Q28584016
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: Maturation of aldose reductase expression in the neonatal rat inner medulla
stated in qid: Q28573013
retrieved: 2019-04-08

source: Regulation of AKR1B1 by thyroid hormone and its receptors
stated in qid: Q28571335
retrieved: 2019-04-08

source: Up-regulation of aldose reductase by the substrate, methylglyoxal
stated in qid: Q28583874
retrieved: 2019-04-08

source: Proteomic changes of PC12 cells treated with proteasomal inhibitor PSI
stated in qid: Q28569104
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2021-11-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2021-09-07

source: ensembl Release 104
stated in qid: Q106833387

wikidata id: Q28556355
domain: protein
level: standard
html url: https://4ort.xyz/entity/aldo-keto-reductase-family-1-member-b-q28556355
markdown url: https://4ort.xyz/entity/aldo-keto-reductase-family-1-member-b-q28556355.md
facts url summary: https://4ort.xyz/entity/aldo-keto-reductase-family-1-member-b-q28556355/facts.json
facts url standard: https://4ort.xyz/entity/aldo-keto-reductase-family-1-member-b-q28556355/facts.json
facts url full: https://4ort.xyz/entity/aldo-keto-reductase-family-1-member-b-q28556355/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-12T00:01:45.983544Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:27:14.058956+00:00Z