# AKT serine/threonine kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21114990](https://www.wikidata.org/wiki/Q21114990)  
**Source**: https://4ort.xyz/entity/akt-serine-threonine-kinase-1


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
4. [Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
5. [Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
6. [Kinetic mechanism of AKT/PKB enzyme family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
7. [A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
8. [The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
9. [PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
10. [Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
11. [The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
12. [A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
13. [Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
14. [Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
15. [c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
16. [A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
17. [COMMD1 downregulates the epithelial sodium channel through Nedd4–2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
18. [KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
19. [The E3 ligase TRAF6 regulates Akt ubiquitination and activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
20. [The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
21. [Regulation of Proapoptotic Mammalian ste20–Like Kinase MST2 by the IGF1-Akt Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
22. [Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
23. [The protooncogene TCL1 is an Akt kinase coactivator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
24. [Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
25. [Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
26. [Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
27. [Phosphorylation of CLK2 at Serine 34 and Threonine 127 by AKT Controls Cell Survival after Ionizing Radiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
28. [DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
29. [Akt/PKB regulates actin organization and cell motility via Girdin/APE](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
30. [FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
31. [BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
32. [Microarray-Assisted Pathway Analysis Identifies MT1X & NFκB as Mediators of TCRP1-Associated Resistance to Cisplatin in Oral Squamous Cell Carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
33. [Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
34. [Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
35. [AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
36. [Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
37. [Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
38. [LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: Impairment of the kinase activity by Parkinson's disease-associated mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
39. [Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
40. [Vimentin is a novel AKT1 target mediating motility and invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
41. [p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
42. [Regulation of TopBP1 oligomerization by Akt/PKB for cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
43. [Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
44. [Evidence for the involvement of FAM110C protein in cell spreading and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
45. [Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
46. [Regulation of human myoblast differentiation by PEBP4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
47. [Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
48. [A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
49. [Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)
50. [Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31749)