# AKT serine/threonine kinase 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28563070](https://www.wikidata.org/wiki/Q28563070)  
**Source**: https://4ort.xyz/entity/akt-serine-threonine-kinase-1-q28563070


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
4. [A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
5. [Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
6. [Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
7. [Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
9. [Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
10. [Ebp1 isoforms distinctively regulate cell survival and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
11. [Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
12. [PKB/Akt partners with Dab2 in albumin endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
13. [Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
14. [Akt1 regulates a JNK scaffold during excitotoxic apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
15. [Glyceraldehyde-3-phosphate dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
16. [Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
17. [Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
18. [PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
19. [Ras GTPase-activating protein binds to Akt and is required for its activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
20. [Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
21. [Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
22. [Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
23. [Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
24. [Effect of recombinant human erythropoietin on hippocampal p-Akt and caspase-9 expressions in rats with status epilepticus and the mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
25. [Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
26. [The mechanisms of EGFR in the regulation of axon regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
27. [Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
28. [Hyaluronan mixed esters of butyric and retinoic acid affording myocardial survival and repair without stem cell transplantation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
29. [Akt-mediated GSK-3beta inhibition prevents migration of polyamine-depleted intestinal epithelial cells via Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
30. [Selective blockade of protein kinase B protects the rat and human myocardium against ischaemic injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
31. [Acute Modulation of Vasoconstrictor Responses by Pravastatin in Small Vessels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
32. [Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
33. [Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
34. [Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
35. [Suppression of Akt1 phosphorylation by adenoviral transfer of the PTEN gene inhibits hypoxia-induced proliferation of rat pulmonary arterial smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47196)
36. ensembl Release 104