Agrin
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P25304
additional property: PropertyValue
  property ID: P361
  value: Concanavalin A-like lectin/glucanase domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Kazal domain superfamily
additional property: PropertyValue
  property ID: P361
  value: SEA domain superfamily
additional property: PropertyValue
  property ID: P527
  value: follistatin-like, N-terminal
additional property: PropertyValue
  property ID: P527
  value: SEA domain
additional property: PropertyValue
  property ID: P527
  value: EGF-like calcium-binding domain
additional property: PropertyValue
  property ID: P637
  value: NP_786930
additional property: PropertyValue
  property ID: P637
  value: XP_006239603
additional property: PropertyValue
  property ID: P637
  value: XP_006239604
additional property: PropertyValue
  property ID: P680
  value: dystroglycan binding
additional property: PropertyValue
  property ID: P680
  value: calcium ion binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: basement membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: regulation of protein phosphorylation
additional property: PropertyValue
  property ID: P682
  value: positive regulation of protein phosphorylation
additional property: PropertyValue
  property ID: P682
  value: chemical synaptic transmission
additional property: PropertyValue
  property ID: P702
  value: Agrn
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000040828
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000050623
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 24
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 24
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P25304
    source count: 1
    confidence: 0.2
  P361:
    value: Q24722342
    source count: 1
    confidence: 0.2
    value label: Concanavalin A-like lectin/glucanase domain superfamily
  P361:
    value: Q41797195
    source count: 1
    confidence: 0.2
    value label: Kazal domain superfamily
  P361:
    value: Q41797478
    source count: 1
    confidence: 0.2
    value label: SEA domain superfamily
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83147017
    source count: 1
    confidence: 0.2
    value label: Laminin G domain, protein family
  P527:
    value: Q24780686
    source count: 1
    confidence: 0.2
    value label: follistatin-like, N-terminal
  P527:
    value: Q24775280
    source count: 1
    confidence: 0.2
    value label: SEA domain
  P527:
    value: Q24772887
    source count: 1
    confidence: 0.2
    value label: EGF-like calcium-binding domain
  P527:
    value: Q24723491
    source count: 1
    confidence: 0.2
    value label: EGF-like domain
  P527:
    value: Q24723468
    source count: 1
    confidence: 0.2
    value label: Laminin EGF domain
  P637:
    value: NP_786930
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006239603
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006239604
    source count: 1
    confidence: 0.2
  P637:
    value: XP_017448655
    source count: 1
    confidence: 0.2
  P637:
    value: XP_017448656
    source count: 1
    confidence: 0.2
  P680:
    value: Q14864268
    source count: 1
    confidence: 0.2
    value label: dystroglycan binding
  P680:
    value: Q14633862
    source count: 3
    confidence: 0.6
    value label: calcium ion binding
  P680:
    value: Q167149
    source count: 6
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q14864020
    source count: 1
    confidence: 0.2
    value label: sialic acid binding
  P680:
    value: Q14897882
    source count: 1
    confidence: 0.2
    value label: chondroitin sulfate binding
  P681:
    value: Q14645596
    source count: 1
    confidence: 0.2
    value label: extracellular region

value: Q32846
source count: 2
confidence: 0.4
value label: basement membrane

value: Q29548
source count: 1
confidence: 0.2
value label: plasma membrane

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q14327652
source count: 1
confidence: 0.2
value label: integral component of membrane

value: Q14851946
source count: 1
confidence: 0.2
value label: regulation of protein phosphorylation

value: Q14819846
source count: 1
confidence: 0.2
value label: positive regulation of protein phosphorylation

value: Q14330653
source count: 1
confidence: 0.2
value label: chemical synaptic transmission

value: Q14645705
source count: 1
confidence: 0.2
value label: multicellular organism development

value: Q1813773
source count: 1
confidence: 0.2
value label: synapse assembly

value: Q24406220
source count: 1
confidence: 0.2
value label: Agrn

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000040828
source count: 1
confidence: 0.2

value: ENSRNOP00000050623
source count: 1
confidence: 0.2

source: Alternative splicing of agrin regulates its binding to heparin alpha-dystroglycan, and the cell surface
stated in qid: Q28574863
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Asparagine of z8 insert is critical for the affinity, conformation, and acetylcholine receptor-clustering activity of neural agrin
stated in qid: Q28579476
retrieved: 2019-05-09

source: Alpha3Na+/K+-ATPase is a neuronal receptor for agrin
stated in qid: Q28577669
retrieved: 2019-05-09

source: Agrin binds BMP2, BMP4 and TGFbeta1
stated in qid: Q24315763
retrieved: 2019-05-09

source: LRP4 serves as a coreceptor of agrin
stated in qid: Q28508023
retrieved: 2019-05-09

source: Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptor
stated in qid: Q28254849
retrieved: 2019-05-09

source: Agrin requires specific proteins to selectively activate γ-aminobutyric acid neurons for pain suppression
stated in qid: Q41166618
retrieved: 2019-05-09

source: Lrp4 is a receptor for Agrin and forms a complex with MuSK
stated in qid: Q28505665
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Agrin becomes concentrated at neuroeffector junctions in developing rodent urinary bladder
stated in qid: Q28584079
retrieved: 2019-02-14

source: Targeting of recombinant agrin to axonal growth cones
stated in qid: Q28567862
retrieved: 2019-05-09

source: The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons
stated in qid: Q28564406
retrieved: 2019-05-09

source: Transmembrane agrin regulates dendritic filopodia and synapse formation in mature hippocampal neuron cultures
stated in qid: Q37308567
retrieved: 2019-05-09

source: Structural basis of agrin-LRP4-MuSK signaling
stated in qid: Q27677019
retrieved: 2019-05-09

source: Agrin mediates a rapid switch from electrical coupling to chemical neurotransmission during synaptogenesis
stated in qid: Q28566547
retrieved: 2019-05-09

source: Agrin regulates rapsyn interaction with surface acetylcholine receptors, and this underlies cytoskeletal anchoring and clustering
stated in qid: Q28565976
retrieved: 2019-05-09

source: Neuregulin inhibits acetylcholine receptor aggregation in myotubes
stated in qid: Q24293736
retrieved: 2019-02-14

source: Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases
stated in qid: Q28578128
retrieved: 2019-05-09

source: Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons
stated in qid: Q28565033
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q28560915
domain: protein
level: standard
html url: https://4ort.xyz/entity/agrin-q28560915
markdown url: https://4ort.xyz/entity/agrin-q28560915.md
facts url summary: https://4ort.xyz/entity/agrin-q28560915/facts.json
facts url standard: https://4ort.xyz/entity/agrin-q28560915/facts.json
facts url full: https://4ort.xyz/entity/agrin-q28560915/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T03:01:47.106934Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:42:22.550026+00:00Z