# Afadin, adherens junction formation factor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21172887](https://www.wikidata.org/wiki/Q21172887)  
**Source**: https://4ort.xyz/entity/afadin-adherens-junction-formation-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P55196)
3. Q20641742
4. [Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
5. [JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
6. [Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
7. [Regulation of c-Src by binding to the PDZ domain of AF-6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
8. [Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
9. [EphA2 proteomics in human keratinocytes reveals a novel association with afadin and epidermal tight junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
10. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55196&geneProductId=UniProtKB:P55196)
11. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
13. [Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
15. [Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55196&geneProductId=UniProtKB:P55196)
17. [The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
18. [Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
19. [Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196)
20. Ensembl Release 99