AF4/FMR2 family member 3
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P51826
additional property: PropertyValue
  property ID: P361
  value: Transcription factor AF4/FMR2
additional property: PropertyValue
  property ID: P637
  value: NP_001020279
additional property: PropertyValue
  property ID: P637
  value: NP_002276
additional property: PropertyValue
  property ID: P637
  value: XP_005264000
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: double-stranded DNA binding
additional property: PropertyValue
  property ID: P680
  value: double-stranded DNA binding
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P682
  value: response to tumor necrosis factor
additional property: PropertyValue
  property ID: P682
  value: regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P682
  value: transcription, DNA-templated
additional property: PropertyValue
  property ID: P702
  value: AFF3
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000317421
additional property: PropertyValue
  property ID: P705
  value: ENSP00000386834
additional property: PropertyValue
  property ID: P705
  value: ENSP00000387207
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 11
      unique citations norm: 0.004
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 11
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P51826
    source count: 1
    confidence: 0.2
  P361:
    value: Q24740678
    source count: 1
    confidence: 0.2
    value label: Transcription factor AF4/FMR2
  P637:
    value: NP_001020279
    source count: 1
    confidence: 0.2
  P637:
    value: NP_002276
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005264000
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005264002
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011509471
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633858
    source count: 1
    confidence: 0.2
    value label: DNA binding
  P680:
    value: Q14818104
    source count: 1
    confidence: 0.2
    value label: double-stranded DNA binding
  P680:
    value: Q14818104
    source count: 2
    confidence: 0.4
    value label: double-stranded DNA binding
  P680:
    value: Q14817979
    source count: 1
    confidence: 0.2
    value label: DNA-binding transcription factor activity
  P681:
    value: Q40260
    source count: 2
    confidence: 0.4
    value label: nucleus
  P681:
    value: Q14817956
    source count: 1
    confidence: 0.2
    value label: nucleoplasm
  P681:
    value: Q220599
    source count: 1
    confidence: 0.2
    value label: cytosol
  P681:
    value: Q14817965
    source count: 1
    confidence: 0.2
    value label: nuclear body
  P681:
    value: Q40260
    source count: 3
    confidence: 0.6
    value label: nucleus
  P682:
    value: Q14599713
    source count: 1
    confidence: 0.2
    value label: response to tumor necrosis factor
  P682:
    value: Q14633883
    source count: 1
    confidence: 0.2
    value label: regulation of transcription, DNA-templated
  P682:
    value: Q14763010
    source count: 1
    confidence: 0.2
    value label: transcription, DNA-templated
  P682:
    value: Q14859949
    source count: 1
    confidence: 0.2
    value label: embryonic hindlimb morphogenesis
  P702:
    value: Q18028427
    source count: 1
    confidence: 0.2
    value label: AFF3
  P703:
    value: Q15978631
    source count: 1
    confidence: 0.2
    value label: Homo sapiens
  P705:
    value: ENSP00000317421
    source count: 1
    confidence: 0.2
  P705:
    value: ENSP00000386834
    source count: 1
    confidence: 0.2
  P705:
    value: ENSP00000387207
    source count: 1
    confidence: 0.2

value: ENSP00000393732
source count: 1
confidence: 0.2

value: ENSP00000395068
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias
stated in qid: Q24316133
retrieved: 2018-03-27

source: LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias
stated in qid: Q24316133
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment
stated in qid: Q24310184
retrieved: 2019-04-08

source: Triangular tibia with fibular aplasia associated with a microdeletion on 2q11.2 encompassing LAF4
stated in qid: Q24311907
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2018-12-05

source: Q20641742
stated in qid: Q20641742
retrieved: 2018-12-07

source: ensembl Release 96
stated in qid: Q63170780

wikidata id: Q21116353
domain: protein
level: standard
html url: https://4ort.xyz/entity/af4-fmr2-family-member-3-q21116353
markdown url: https://4ort.xyz/entity/af4-fmr2-family-member-3-q21116353.md
facts url summary: https://4ort.xyz/entity/af4-fmr2-family-member-3-q21116353/facts.json
facts url standard: https://4ort.xyz/entity/af4-fmr2-family-member-3-q21116353/facts.json
facts url full: https://4ort.xyz/entity/af4-fmr2-family-member-3-q21116353/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-03T03:40:16.194729Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:57:03.164433+00:00Z