# Adrenoceptor alpha 2A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4734892](https://www.wikidata.org/wiki/Q4734892)  
**Source**: https://4ort.xyz/entity/adrenoceptor-alpha-2a


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL677)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL679)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1437)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL211456)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200379)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200833)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200791)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200787)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2106195)
12. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08913)
13. Q20641742
14. [Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
16. [Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
17. [An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913)
19. [Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
20. [A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
21. [Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
22. [Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
24. [Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913)
25. [An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913)
26. [Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913)
27. [EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
28. [Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
29. [A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913)
30. [Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913)
31. [Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
32. [Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
33. [Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
34. [Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
35. [Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
36. [Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
37. [Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913)
38. [Heterodimerization of alpha 2A- and beta 1-adrenergic receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913)
39. Ensembl Release 99