# ADP ribosylation factor guanine nucleotide exchange factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115544](https://www.wikidata.org/wiki/Q21115544)  
**Source**: https://4ort.xyz/entity/adp-ribosylation-factor-guanine-nucleotide-exchange-factor-1-q21115544


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Y6D6)
3. Q20641742
4. [BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
6. [A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
7. [ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
8. [Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
9. [Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
10. [Interaction of brefeldin A-inhibited guanine nucleotide-exchange protein (BIG) 1 and kinesin motor protein KIF21A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
11. [Association of guanine nucleotide-exchange protein BIG1 in HepG2 cell nuclei with nucleolin, U3 snoRNA, and fibrillarin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
12. [Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
13. [Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
14. [AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
15. [Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
17. [Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
18. [Specific Functions of BIG1 and BIG2 in Endomembrane Organization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
19. [BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
20. [Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6D6)
21. Ensembl Release 99