Adenylate cyclase 5
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Adenylate cyclase, animals
additional property: PropertyValue
  property ID: P361
  value: Nucleotide cyclase
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P527
  value: Adenylate cyclase, conserved domain
additional property: PropertyValue
  property ID: P527
  value: Adenylate cyclase, N-terminal
additional property: PropertyValue
  property ID: P527
  value: Adenylyl cyclase class-3/4/guanylyl cyclase
additional property: PropertyValue
  property ID: P637
  value: NP_072122
additional property: PropertyValue
  property ID: P637
  value: XP_017453557
additional property: PropertyValue
  property ID: P637
  value: XP_038944541
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: adenylate cyclase activity
additional property: PropertyValue
  property ID: P680
  value: ATP binding
additional property: PropertyValue
  property ID: P681
  value: endosome
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P681
  value: integral component of plasma membrane
additional property: PropertyValue
  property ID: P682
  value: cAMP biosynthetic process
additional property: PropertyValue
  property ID: P682
  value: adenylate cyclase-activating G protein-coupled receptor signaling pathway
additional property: PropertyValue
  property ID: P682
  value: positive regulation of cytosolic calcium ion concentration
additional property: PropertyValue
  property ID: P702
  value: Adcy5
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000046488
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 19
      unique citations norm: 0.007
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 19
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q04400
    source count: 1
    confidence: 0.2
  P361:
    value: Q24771780
    source count: 1
    confidence: 0.2
    value label: Adenylate cyclase, animals
  P361:
    value: Q24779685
    source count: 1
    confidence: 0.2
    value label: Nucleotide cyclase
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83163521
    source count: 1
    confidence: 0.2
    value label: Adenylate cyclase, N-terminal domain, protein family
  P361:
    value: Q83146552
    source count: 1
    confidence: 0.2
    value label: Adenylate cyclase, conserved domain, protein family
  P527:
    value: Q24778702
    source count: 1
    confidence: 0.2
    value label: Adenylate cyclase, conserved domain
  P527:
    value: Q24783525
    source count: 1
    confidence: 0.2
    value label: Adenylate cyclase, N-terminal
  P527:
    value: Q24768262
    source count: 1
    confidence: 0.2
    value label: Adenylyl cyclase class-3/4/guanylyl cyclase
  P527:
    value: Q24744824
    source count: 1
    confidence: 0.2
    value label: Adenylyl cyclase class-4/guanylyl cyclase, conserved site
  P637:
    value: NP_072122
    source count: 1
    confidence: 0.2
  P637:
    value: XP_017453557
    source count: 1
    confidence: 0.2
  P637:
    value: XP_038944541
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14905149
    source count: 7
    confidence: 1.0
    value label: adenylate cyclase activity
  P680:
    value: Q14817981
    source count: 1
    confidence: 0.2
    value label: ATP binding
  P680:
    value: Q21111190
    source count: 1
    confidence: 0.2
    value label: calcium- and calmodulin-responsive adenylate cyclase activity
  P680:
    value: Q14859873
    source count: 1
    confidence: 0.2
    value label: lyase activity
  P681:
    value: Q824237
    source count: 1
    confidence: 0.2
    value label: endosome
  P681:
    value: Q29548
    source count: 4
    confidence: 0.8
    value label: plasma membrane
  P681:
    value: Q14859540
    source count: 1
    confidence: 0.2
    value label: integral component of plasma membrane
  P681:
    value: Q180436
    source count: 2
    confidence: 0.4
    value label: cilium
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane

value: Q14905151
source count: 6
confidence: 1.0
value label: cAMP biosynthetic process

value: Q14860468
source count: 3
confidence: 0.6
value label: adenylate cyclase-activating G protein-coupled receptor signaling pathway

value: Q14820654
source count: 1
confidence: 0.2
value label: positive regulation of cytosolic calcium ion concentration

value: Q14330969
source count: 1
confidence: 0.2
value label: brain development

value: Q471817
source count: 1
confidence: 0.2
value label: development of the heart

value: Q24395832
source count: 1
confidence: 0.2
value label: Adcy5

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000046488
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases
stated in qid: Q28571958
retrieved: 2019-02-14

source: Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes
stated in qid: Q28568726
retrieved: 2019-02-14

source: Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts
stated in qid: Q28569021
retrieved: 2019-02-14

source: Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver
stated in qid: Q28570531
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Cellular localization of type 5 and type 6 ACs in collecting duct and regulation of cAMP synthesis
stated in qid: Q28567878
retrieved: 2019-02-14

source: Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle
stated in qid: Q28570811
retrieved: 2019-02-14

source: G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes
stated in qid: Q28566417
retrieved: 2019-02-14

source: Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft)
stated in qid: Q28569986
retrieved: 2019-02-14

source: Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons
stated in qid: Q28577675
retrieved: 2019-02-14

source: Differential expression of type I, II, and V adenylyl cyclase gene in the postnatal developing rat brain.
stated in qid: Q42528859
retrieved: 2019-02-14

source: Adenylyl cyclase type 5 protein expression during cardiac development and stress.
stated in qid: Q37430967
retrieved: 2019-02-14

source: Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25
stated in qid: Q28511414
retrieved: 2019-02-14

source: Effects of chronic morphine and morphine withdrawal on gene expression in rat peripheral blood mononuclear cells
stated in qid: Q46359740
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q28561001
domain: protein
level: standard
html url: https://4ort.xyz/entity/adenylate-cyclase-5
markdown url: https://4ort.xyz/entity/adenylate-cyclase-5.md
facts url summary: https://4ort.xyz/entity/adenylate-cyclase-5/facts.json
facts url standard: https://4ort.xyz/entity/adenylate-cyclase-5/facts.json
facts url full: https://4ort.xyz/entity/adenylate-cyclase-5/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T12:34:28.538928Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:13:20.947238+00:00Z