# Adenomatous polyposis coli protein

> mouse protein (annotated by UniProtKB/Swiss-Prot Q61315)

**Wikidata**: [Q21494863](https://www.wikidata.org/wiki/Q21494863)  
**Source**: https://4ort.xyz/entity/adenomatous-polyposis-coli-protein-q21494863


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q61315)
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
5. [The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
6. [Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
7. [Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
8. [Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
9. [Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
10. [Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
11. [Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
12. [Putative tumor suppressor EDD interacts with and up-regulates APC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
13. [Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
14. [The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
15. [Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
17. [The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
18. [Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
19. [Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
20. [NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
21. [Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
22. [Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
23. [Apc tumor suppressor gene is the "zonation-keeper" of mouse liver](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
24. [APC inhibits ERK pathway activation and cellular proliferation induced by RAS](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
25. [Loss of adenomatous polyposis coli gene function disrupts thymic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
26. [Interleukin-6 and cachexia in ApcMin/+ mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
27. [Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
28. [Apc tumor suppressor gene is the "zonation-keeper" of mouse liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
29. [Disruption of early proximodistal patterning and AVE formation in Apc mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
30. [Inactivation of Apc in the mouse prostate causes prostate carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
31. [Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
32. [Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
33. [Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
34. [Deficiency of Mbd2 attenuates Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
35. [Adenomatous polyposis coli (APC) is required for normal development of skin and thymus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
36. [A critical role for Apc in hematopoietic stem and progenitor cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
37. [Essential role of beta-catenin in postnatal bone acquisition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
38. [APC mutation and the crypt cycle in murine and human intestine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
39. [Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
40. [Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
41. [The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
42. [Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
43. [Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
44. [Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61315&geneProductId=UniProtKB:Q61315)
45. [Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
46. [Inactivation of both APC alleles in human and mouse tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
47. [Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
48. [Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
49. [Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)
50. [APC-dependent suppression of colon carcinogenesis by PPARgamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61315)