ADAM metallopeptidase with thrombospondin type 1 motif 12
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P58397
additional property: PropertyValue
  property ID: P361
  value: Thrombospondin type-1 (TSP1) repeat superfamily
additional property: PropertyValue
  property ID: P361
  value: Metallopeptidase, catalytic domain superfamily
additional property: PropertyValue
  property ID: P361
  value: ADAMTS/ADAMTS-like
additional property: PropertyValue
  property ID: P527
  value: Thrombospondin type-1 (TSP1) repeat
additional property: PropertyValue
  property ID: P527
  value: PLAC
additional property: PropertyValue
  property ID: P527
  value: Peptidase M12B, ADAM/reprolysin
additional property: PropertyValue
  property ID: P637
  value: NP_001311440
additional property: PropertyValue
  property ID: P637
  value: NP_001311441
additional property: PropertyValue
  property ID: P637
  value: NP_112217
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P680
  value: peptidase activity
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: extracellular matrix
additional property: PropertyValue
  property ID: P681
  value: collagen-containing extracellular matrix
additional property: PropertyValue
  property ID: P682
  value: regulation of endothelial tube morphogenesis
additional property: PropertyValue
  property ID: P682
  value: proteoglycan catabolic process
additional property: PropertyValue
  property ID: P682
  value: negative regulation of hepatocyte growth factor receptor signaling pathway
additional property: PropertyValue
  property ID: P702
  value: ADAMTS12
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000344847
additional property: PropertyValue
  property ID: P705
  value: ENSP00000422554
additional property: PropertyValue
  property ID: P705
  value: ENSP00000421638
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 14
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 14
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P58397
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797497
    source count: 1
    confidence: 0.2
    value label: Thrombospondin type-1 (TSP1) repeat superfamily
  P361:
    value: Q24778214
    source count: 1
    confidence: 0.2
    value label: Metallopeptidase, catalytic domain superfamily
  P361:
    value: Q24782924
    source count: 1
    confidence: 0.2
    value label: ADAMTS/ADAMTS-like
  P361:
    value: Q83146782
    source count: 1
    confidence: 0.2
    value label: Peptidase M12B, ADAM/reprolysin, protein family
  P361:
    value: Q83140125
    source count: 1
    confidence: 0.2
    value label: ADAM-TS Spacer 1, protein family
  P527:
    value: Q24772391
    source count: 1
    confidence: 0.2
    value label: Thrombospondin type-1 (TSP1) repeat
  P527:
    value: Q24777719
    source count: 1
    confidence: 0.2
    value label: PLAC
  P527:
    value: Q24779105
    source count: 1
    confidence: 0.2
    value label: Peptidase M12B, ADAM/reprolysin
  P527:
    value: Q24770691
    source count: 1
    confidence: 0.2
    value label: ADAM-TS Spacer 1
  P527:
    value: Q24720633
    source count: 1
    confidence: 0.2
    value label: Peptidase M12B, propeptide
  P637:
    value: NP_001311440
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001311441
    source count: 1
    confidence: 0.2
  P637:
    value: NP_112217
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016865394
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016865395
    source count: 1
    confidence: 0.2
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P680:
    value: Q14645703
    source count: 2
    confidence: 0.4
    value label: peptidase activity
  P680:
    value: Q167149
    source count: 5
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q14865288
    source count: 4
    confidence: 0.8
    value label: metalloendopeptidase activity
  P680:
    value: Q14353168
    source count: 1
    confidence: 0.2
    value label: hydrolase activity
  P681:
    value: Q14645596
    source count: 1
    confidence: 0.2
    value label: extracellular region

value: Q193825
source count: 1
confidence: 0.2
value label: extracellular matrix

value: Q54810453
source count: 1
confidence: 0.2
value label: collagen-containing extracellular matrix

value: Q21095567
source count: 1
confidence: 0.2
value label: regulation of endothelial tube morphogenesis

value: Q21105322
source count: 1
confidence: 0.2
value label: proteoglycan catabolic process

value: Q21105323
source count: 1
confidence: 0.2
value label: negative regulation of hepatocyte growth factor receptor signaling pathway

value: Q21105324
source count: 1
confidence: 0.2
value label: negative regulation of cellular response to vascular endothelial growth factor stimulus

value: Q14875882
source count: 1
confidence: 0.2
value label: cellular response to tumor necrosis factor

value: Q18047096
source count: 1
confidence: 0.2
value label: ADAMTS12

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000344847
source count: 1
confidence: 0.2

value: ENSP00000422554
source count: 1
confidence: 0.2

value: ENSP00000421638
source count: 1
confidence: 0.2

value: ENSP00000486213
source count: 1
confidence: 0.2

value: ENSP00000486915
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: A proteome-scale map of the human interactome network
stated in qid: Q24307146
retrieved: 2019-04-08

source: ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein
stated in qid: Q24317122
retrieved: 2019-04-08

source: Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin
stated in qid: Q24313406
retrieved: 2019-04-08

source: The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway
stated in qid: Q24294986
retrieved: 2019-04-08

source: Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats
stated in qid: Q24291052
retrieved: 2018-04-24

source: Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats
stated in qid: Q24291052
retrieved: 2018-01-01

source: Negative effects of ADAMTS‐7 and ADAMTS‐12 on endplate cartilage differentiation
stated in qid: Q24302021
retrieved: 2019-04-08

source: ADAMTS-12 metalloprotease is necessary for normal inflammatory response
stated in qid: Q24299706
retrieved: 2019-04-08

source: Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?
stated in qid: Q24299809
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21105326
domain: protein
level: standard
html url: https://4ort.xyz/entity/adam-metallopeptidase-with-thrombospondin-type-1-motif-12-q21105326
markdown url: https://4ort.xyz/entity/adam-metallopeptidase-with-thrombospondin-type-1-motif-12-q21105326.md
facts url summary: https://4ort.xyz/entity/adam-metallopeptidase-with-thrombospondin-type-1-motif-12-q21105326/facts.json
facts url standard: https://4ort.xyz/entity/adam-metallopeptidase-with-thrombospondin-type-1-motif-12-q21105326/facts.json
facts url full: https://4ort.xyz/entity/adam-metallopeptidase-with-thrombospondin-type-1-motif-12-q21105326/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-11T22:33:34.048191Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:25:14.046139+00:00Z