# Activin A receptor like type 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4650909](https://www.wikidata.org/wiki/Q4650909)  
**Source**: https://4ort.xyz/entity/activin-a-receptor-like-type-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P37023)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
5. [Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023)
6. [SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
7. [Regulation of ALK-1 signaling by the nuclear receptor LXRbeta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
8. [Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
9. [Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
10. [Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
11. [Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
12. [Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
13. [LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
14. [Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
15. [Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
16. [Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
17. [Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
18. [S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
19. [Functional and splicing defect analysis of 23 ACVRL1 mutations in a cohort of patients affected by Hereditary Hemorrhagic Telangiectasia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023)
20. [Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
21. [SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7](http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
23. [Functional and splicing defect analysis of 23 ACVRL1 mutations in a cohort of patients affected by Hereditary Hemorrhagic Telangiectasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
24. [Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
25. [Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
26. [BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
27. [ALK1 signaling regulates early postnatal lymphatic vessel development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
28. [Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
29. [Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
30. [Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023)
32. [Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023)
33. Ensembl Release 99