# activating transcription factor 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116808](https://www.wikidata.org/wiki/Q21116808)  
**Source**: https://4ort.xyz/entity/activating-transcription-factor-6-q21116808


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P18850)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
5. [XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
6. [Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
7. [Interaction of ATF6 and serum response factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
8. [ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
9. [ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
10. [Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
11. [A thrombospondin-dependent pathway for a protective ER stress response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
12. [Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
13. [Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
14. [The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
15. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
16. [ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850)
18. [Impact of cytosine methylation on DNA binding specificities of human transcription factors.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
19. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
20. [CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
21. [Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
22. [Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
23. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850)
24. [ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850)
25. [Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850)
26. [Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18850&geneProductId=UniProtKB:P18850)
27. [Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
28. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
29. [hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
30. [Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
31. [Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18850)
32. Ensembl Release 99
33. UMLS 2023