# Activating transcription factor 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21102119](https://www.wikidata.org/wiki/Q21102119)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/ATF4)  
**Source**: https://4ort.xyz/entity/activating-transcription-factor-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P18848)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q96AQ3)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
7. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q96AQ3)
8. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q96AQ3)
9. [C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
10. [SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
11. [Mitosin/CENP-F as a negative regulator of activating transcription factor-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
12. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
13. [DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
14. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
15. [ZIP Kinase, a Novel Serine/Threonine Kinase Which Mediates Apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
16. [New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
17. [Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
18. [ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
19. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
20. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
21. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
22. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
23. [Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
24. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
25. [Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
26. [Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
27. [Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
28. [ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
29. [Shifted Transversal Design smart-pooling for high coverage interactome mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
30. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
31. [The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
32. [The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
33. [TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
34. [All roads lead to ATF4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
35. [The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
36. [The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
37. [Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
38. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848)
39. [Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848)
40. [The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848)
41. [Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848)
42. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
43. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
44. [Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
45. [ATF4 Protects Against Neuronal Death in Cellular Parkinson's Disease Models by Maintaining Levels of Parkin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
46. [ATF4 Protects Against Neuronal Death in Cellular Parkinson's Disease Models by Maintaining Levels of Parkin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848)
47. [The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848)
48. [Roles of CHOP/GADD153 in endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
49. [Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)
50. [Source](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848)