# Activating transcription factor 4

> mammalian protein found in Mus musculus

**Wikidata**: [Q21981491](https://www.wikidata.org/wiki/Q21981491)  
**Source**: https://4ort.xyz/entity/activating-transcription-factor-4-q21981491


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q06507)
3. Q20641742
4. [The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507)
5. [Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
7. [The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
8. [cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507)
9. [The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
10. [FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
11. [cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
12. [Mouse NIPK interacts with ATF4 and affects its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
13. [Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
14. [DISC1, PDE4B, and NDE1 at the centrosome and synapse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
15. [ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
16. [SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
17. [The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
18. [ZIP Kinase, a Novel Serine/Threonine Kinase Which Mediates Apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
19. [ZIP kinase triggers apoptosis from nuclear PML oncogenic domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
20. [ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
21. [Leptin regulation of bone resorption by the sympathetic nervous system and CART](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507)
23. [cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
25. [FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
26. [Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
27. [FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507)
28. [Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507)
29. [ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507)
30. [The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507)
31. [Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
32. [Regulated translation initiation controls stress-induced gene expression in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
33. [The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
34. [Mouse NIPK interacts with ATF4 and affects its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507)
35. [TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
36. [Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507)
37. [Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507)
38. [Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
39. [Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507)
40. ensembl Release 106