# Actinin alpha 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21096355](https://www.wikidata.org/wiki/Q21096355)  
**Source**: https://4ort.xyz/entity/actinin-alpha-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O43707)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
5. [Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
7. [α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
8. [Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
9. [Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
10. [Renal alpha-actinin-4: purification and puromycin aminonucleoside-binding property](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
11. [Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
12. [Structural dynamics of alpha-actinin-vinculin interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
13. [Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
14. [Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
15. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
16. [Influenza A viral nucleoprotein interacts with cytoskeleton scaffolding protein α-actinin-4 for viral replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
17. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
18. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
19. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
20. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
21. [E-cadherin regulates the association between beta-catenin and actinin-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
22. [IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
23. [Shifted Transversal Design smart-pooling for high coverage interactome mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
24. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
25. [Alpha-actinin binding kinetics modulate cellular dynamics and force generation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
26. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
27. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
28. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
29. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
30. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
31. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
32. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
33. [Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
34. [Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
35. [Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
36. [α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
37. [Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
38. [Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
39. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
40. [α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
41. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43707&geneProductId=UniProtKB:O43707)
42. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
43. [Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
44. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
45. [Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
46. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
47. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
48. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
49. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)
50. [Molecular composition of IMP1 ribonucleoprotein granules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43707)