# Actinin alpha 4

> mammalian protein found in Mus musculus

**Wikidata**: [Q21491080](https://www.wikidata.org/wiki/Q21491080)  
**Source**: https://4ort.xyz/entity/actinin-alpha-4-q21491080


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P57780)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
5. [Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
6. [Involvement of actinin-4 in the recruitment of JRAB/MICAL-L2 to cell-cell junctions and the formation of functional tight junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
7. [Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
8. [α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
9. [Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
10. [Hypoxia inactivates inducible nitric oxide synthase in mouse macrophages by disrupting its interaction with alpha-actinin 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
11. [RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
12. [The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
13. [Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P57780&geneProductId=UniProtKB:P57780)
15. [Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
16. [α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=P57780&geneProductId=UniProtKB:P57780)
17. [Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
18. [CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
19. [Actinin-4 is preferentially involved in circular ruffling and macropinocytosis in mouse macrophages: analysis by fluorescence ratio imaging](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P57780)
20. ensembl Release 106