# Actinin alpha 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21096383](https://www.wikidata.org/wiki/Q21096383)  
**Source**: https://4ort.xyz/entity/actinin-alpha-1-q21096383


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P12814)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
5. [Dynamics of alpha-actinin in focal adhesions and stress fibers visualized with alpha-actinin-green fluorescent protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
6. [Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
7. [Direct binding of alpha-actinin enhances TRPP3 channel activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
8. [Structural dynamics of alpha-actinin-vinculin interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
9. [Modulation of alpha-actinin levels affects cell motility and confers tumorigenicity on 3T3 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
10. [Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
11. [Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
12. [Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
13. [The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
14. [ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
15. [Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
16. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
17. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
18. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
19. [Direct interaction between α‐actinin and hepatitis C virus NS5B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
20. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
21. [Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
22. [UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
23. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
24. [Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
25. [Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
26. [α-Actinin Anchors PSD-95 at Postsynaptic Sites.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
27. [ACTN1 mutations cause congenital macrothrombocytopenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
28. [Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
29. [Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12814&geneProductId=UniProtKB:P12814)
30. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12814&geneProductId=UniProtKB:P12814)
31. [Dynamics of alpha-actinin in focal adhesions and stress fibers visualized with alpha-actinin-green fluorescent protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12814&geneProductId=UniProtKB:P12814)
32. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12814&geneProductId=UniProtKB:P12814)
33. [α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12814&geneProductId=UniProtKB:P12814)
34. [A Missense Mutation in the Alpha-Actinin 1 Gene (ACTN1) Is the Cause of Autosomal Dominant Macrothrombocytopenia in a Large French Family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
35. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12814&geneProductId=UniProtKB:P12814)
36. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12814&geneProductId=UniProtKB:P12814)
37. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12814&geneProductId=UniProtKB:P12814)
38. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12814&geneProductId=UniProtKB:P12814)
39. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12814&geneProductId=UniProtKB:P12814)
40. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
41. [Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
42. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
43. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
44. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
45. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
46. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12814)
47. Ensembl Release 99