Acrosin prepropeptide
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P23578
additional property: PropertyValue
  property ID: P361
  value: peptidase S1A, acrosin
additional property: PropertyValue
  property ID: P361
  value: Peptidase S1, PA clan
additional property: PropertyValue
  property ID: P361
  value: Serine proteases, trypsin domain, protein family
additional property: PropertyValue
  property ID: P527
  value: serine proteases, trypsin domain
additional property: PropertyValue
  property ID: P527
  value: Serine proteases, trypsin family, serine active site
additional property: PropertyValue
  property ID: P527
  value: serine proteases, trypsin family, histidine active site
additional property: PropertyValue
  property ID: P637
  value: NP_001191978
additional property: PropertyValue
  property ID: P637
  value: NP_001264174
additional property: PropertyValue
  property ID: P637
  value: NP_001264175
additional property: PropertyValue
  property ID: P680
  value: peptidase activity
additional property: PropertyValue
  property ID: P680
  value: serine-type endopeptidase activity
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: acrosomal matrix
additional property: PropertyValue
  property ID: P681
  value: protein-containing complex
additional property: PropertyValue
  property ID: P681
  value: acrosomal vesicle
additional property: PropertyValue
  property ID: P682
  value: acrosome reaction
additional property: PropertyValue
  property ID: P682
  value: proteolysis
additional property: PropertyValue
  property ID: P682
  value: activation of adenylate cyclase activity
additional property: PropertyValue
  property ID: P702
  value: Acr
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000023295
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000155369
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000154827
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 15
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 15
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P23578
    source count: 1
    confidence: 0.2
  P361:
    value: Q24740162
    source count: 1
    confidence: 0.2
    value label: peptidase S1A, acrosin
  P361:
    value: Q24783967
    source count: 1
    confidence: 0.2
    value label: Peptidase S1, PA clan
  P361:
    value: Q83146087
    source count: 1
    confidence: 0.2
    value label: Serine proteases, trypsin domain, protein family
  P361:
    value: Q95352336
    source count: 1
    confidence: 0.2
    value label: Serine proteases, trypsin family, histidine active site, protein family
  P361:
    value: Q95351373
    source count: 1
    confidence: 0.2
    value label: Serine proteases, trypsin family, serine active site, protein family
  P527:
    value: Q24777164
    source count: 1
    confidence: 0.2
    value label: serine proteases, trypsin domain
  P527:
    value: Q24724853
    source count: 1
    confidence: 0.2
    value label: Serine proteases, trypsin family, serine active site
  P527:
    value: Q24726204
    source count: 1
    confidence: 0.2
    value label: serine proteases, trypsin family, histidine active site
  P637:
    value: NP_001191978
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001264174
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001264175
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001264176
    source count: 1
    confidence: 0.2
  P637:
    value: NP_038483
    source count: 1
    confidence: 0.2
  P680:
    value: Q14645703
    source count: 3
    confidence: 0.6
    value label: peptidase activity
  P680:
    value: Q14820947
    source count: 5
    confidence: 1.0
    value label: serine-type endopeptidase activity
  P680:
    value: Q167149
    source count: 1
    confidence: 0.2
    value label: protein binding
  P680:
    value: Q14864896
    source count: 3
    confidence: 0.6
    value label: mannose binding
  P680:
    value: Q14353168
    source count: 1
    confidence: 0.2
    value label: hydrolase activity
  P681:
    value: Q14864894
    source count: 1
    confidence: 0.2
    value label: acrosomal matrix

value: Q22325163
source count: 2
confidence: 0.4
value label: protein-containing complex

value: Q421111
source count: 4
confidence: 0.8
value label: acrosomal vesicle

value: Q14864893
source count: 2
confidence: 0.4
value label: Golgi-associated vesicle

value: Q163261
source count: 4
confidence: 0.8
value label: acrosome reaction

value: Q33123
source count: 2
confidence: 0.4
value label: proteolysis

value: Q14860503
source count: 3
confidence: 0.6
value label: activation of adenylate cyclase activity

value: Q14864900
source count: 1
confidence: 0.2
value label: single fertilization

value: Q14864901
source count: 1
confidence: 0.2
value label: binding of sperm to zona pellucida

value: Q14864906
source count: 1
confidence: 0.2
value label: Acr

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000023295
source count: 1
confidence: 0.2

value: ENSMUSP00000155369
source count: 1
confidence: 0.2

value: ENSMUSP00000154827
source count: 1
confidence: 0.2

value: ENSMUSP00000155444
source count: 1
confidence: 0.2

source: Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization
stated in qid: Q28591773
retrieved: 2019-02-14

source: Spermatozoa lacking acrosin protein show delayed fertilization
stated in qid: Q28584814
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Role of acrosomal matrix proteases in sperm-zona pellucida interactions
stated in qid: Q24313201
retrieved: 2018-04-24

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization
stated in qid: Q28591622
retrieved: 2019-02-14

source: Role of acrosomal matrix proteases in sperm-zona pellucida interactions
stated in qid: Q24313201
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Functional and molecular characterization of the transcriptional regulatory region of the proacrosin gene
stated in qid: Q28585588
retrieved: 2019-02-14

source: Triple knockouts reveal gene interactions affecting fertility of male mice
stated in qid: Q28586150
retrieved: 2019-02-14

source: Synergistic effects of germ cell expressed genes on male fertility in mice
stated in qid: Q28512032
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q14864907
domain: protein
level: standard
html url: https://4ort.xyz/entity/acrosin-prepropeptide
markdown url: https://4ort.xyz/entity/acrosin-prepropeptide.md
facts url summary: https://4ort.xyz/entity/acrosin-prepropeptide/facts.json
facts url standard: https://4ort.xyz/entity/acrosin-prepropeptide/facts.json
facts url full: https://4ort.xyz/entity/acrosin-prepropeptide/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-28T15:55:36.039959Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:10:40.945259+00:00Z