# ACD shelterin complex subunit and telomerase recruitment factor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21104930](https://www.wikidata.org/wiki/Q21104930)  
**Source**: https://4ort.xyz/entity/acd-shelterin-complex-subunit-and-telomerase-recruitment-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96AP0)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0)
6. [HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0)
7. [Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
8. [The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
9. [TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
10. [OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
11. [Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
12. [Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
13. [Telomere protection by mammalian Pot1 requires interaction with Tpp1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
14. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
15. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
16. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
17. [A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
18. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
19. [Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
20. [The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
21. [POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
22. [The POT1-TPP1 telomere complex is a telomerase processivity factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
23. [The human CST complex is a terminator of telomerase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
24. [PTOP interacts with POT1 and regulates its localization to telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
25. [A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
26. [HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
28. [The POT1-TPP1 telomere complex is a telomerase processivity factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0)
29. [Characterization of the DNA binding specificity of Shelterin complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0)
30. [Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0)
31. [Characterization of the DNA binding specificity of Shelterin complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
32. [Tpp1/Acd maintains genomic stability through a complex role in telomere protection](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0)
33. [PTOP interacts with POT1 and regulates its localization to telomeres](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0)
34. [Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
35. [TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0)
36. [Telomere protection by mammalian Pot1 requires interaction with Tpp1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0)
37. [The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0)
38. [Tpp1/Acd maintains genomic stability through a complex role in telomere protection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0)
39. Ensembl Release 99
40. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)