# ABL proto-oncogene 1, non-receptor tyrosine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q587961](https://www.wikidata.org/wiki/Q587961)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/ABL_(gene))  
**Source**: https://4ort.xyz/entity/abl-proto-oncogene-1-non-receptor-tyrosine-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL941)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1171837)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL217092)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1738757)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3948730)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1642)
9. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P00519)
10. Q20641742
11. Freebase Data Dumps. 2013
12. [ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
14. [Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
15. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P00519)
16. [c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
17. [Protein binding and signaling properties of RIN1 suggest a unique effector function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
18. [The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P00519)
19. [Regulation of Rad51 Function by c-Abl in Response to DNA Damage](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P00519)
20. [c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
21. [Regulation of Rad51 Function by c-Abl in Response to DNA Damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
22. [Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
23. [Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
24. [Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
25. [Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
26. [NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
27. [Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
28. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
29. [Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
30. [JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
31. [Abl kinase interacts with and phosphorylates vinexin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
32. [Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
33. [Physical and functional interaction between hMSH5 and c-Abl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
34. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
35. [Evidence for a direct involvement of hMSH5 in promoting ionizing radiation induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
36. [Characterization of p87C3G, a novel, truncated C3G isoform that is overexpressed in chronic myeloid leukemia and interacts with Bcr-Abl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
37. [RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
38. [c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
39. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
40. [The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
41. [Interaction between ATM protein and c-Abl in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
42. [c-Abl kinase is required for beta 2 integrin-mediated neutrophil adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
43. [Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
44. [Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
45. [Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
46. [MutS homologue hMSH5: role in cisplatin-induced DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
47. [Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
48. [BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
49. [Identification of a Candidate Human Spectrin Src Homology 3 Domain-binding Protein Suggests a General Mechanism of Association of Tyrosine Kinases with the Spectrin-based Membrane Skeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)
50. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00519)