# AAA family ATPase CDC48 YDL126C

> fungal protein found in Saccharomyces cerevisiae S288c

**Wikidata**: [Q27548297](https://www.wikidata.org/wiki/Q27548297)  
**Source**: https://4ort.xyz/entity/aaa-family-atpase-cdc48-ydl126c


## References

1. UniProt
2. Q20641742
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P25694)
4. [The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP-, and NADH-concentrations and is completely inhibited by NEM.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
6. [Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
7. [High-quality binary protein interaction map of the yeast interactome network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
8. [Proteome survey reveals modularity of the yeast cell machinery](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
9. [A comprehensive two-hybrid analysis to explore the yeast protein interactome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
10. [Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51–Rad52 interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
11. [Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
12. [Sel1p/Ubx2p participates in a distinct Cdc48p-dependent endoplasmic reticulum-associated degradation pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
13. [Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
14. [Ubx2 links the Cdc48 complex to ER-associated protein degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
15. [Global landscape of protein complexes in the yeast Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
16. [Sec61p is part of the endoplasmic reticulum-associated degradation machinery](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
17. [Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
18. [The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
19. [Functional organization of the yeast proteome by systematic analysis of protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
20. [Key steps in ERAD of luminal ER proteins reconstituted with purified components](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
21. [The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
22. [The Cdc48 ATPase modulates the interaction between two proteolytic factors Ufd2 and Rad23.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
23. [NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
24. [A stress-responsive system for mitochondrial protein degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
25. [Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
26. [Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
27. [Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
28. [An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
29. [The Budding Yeast Cdc48Shp1 Complex Promotes Cell Cycle Progression by Positive Regulation of Protein Phosphatase 1 (Glc7)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
30. [A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
31. [The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
32. [Tyrosine Phosphorylation Regulates Cell Cycle-dependent Nuclear Localization of Cdc48p](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
33. [Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
34. [A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
35. [Pkc1p modifies CPY* degradation in the ERAD pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
36. [HRD4/NPL4Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
37. [AAA-ATPase p97/Cdc48p, a Cytosolic Chaperone Required for Endoplasmic Reticulum-Associated Protein Degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
38. [Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
39. [Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
40. [Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
41. [The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
42. [Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
43. [Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
44. [The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
45. [40S subunit dissociation and proteasome-dependent RNA degradation in nonfunctional 25S rRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
46. [Signal-Induced Disassembly of the SCF Ubiquitin Ligase Complex by Cdc48/p97](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
47. [The AAA-ATPase Cdc48 and cofactor Shp1 promote chromosome bi-orientation by balancing Aurora B activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
48. [The Cdc48–Ufd1–Npl4 complex is central in ubiquitin–proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
49. [The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)
50. [The Cdc48 protein and its cofactor Vms1 are involved in Cdc13 protein degradation.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694)