# A-Raf proto-oncogene, serine/threonine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109211](https://www.wikidata.org/wiki/Q21109211)  
**Source**: https://4ort.xyz/entity/a-raf-proto-oncogene-serine-threonine-kinase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P10398)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
5. [The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10398&geneProductId=UniProtKB:P10398)
7. [Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10398&geneProductId=UniProtKB:P10398)
8. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
9. [Identification of interaction between MEK2 and A-Raf-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
10. [Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
11. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
12. [Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
13. [A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
14. [Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
15. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
16. [Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
17. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
18. [Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
19. [RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
20. [Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
21. [A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
22. [Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
23. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
24. [Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
26. [PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10398)
27. Ensembl Release 99
28. UMLS 2023