# 5-hydroxytryptamine receptor 2B

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4639596](https://www.wikidata.org/wiki/Q4639596)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/5-HT2B_receptor)  
**Source**: https://4ort.xyz/entity/5-hydroxytryptamine-receptor-2b


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL37744)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P41595)
5. Q20641742
6. Freebase Data Dumps. 2013
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
9. [Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595)
10. [The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595)
11. [The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595)
12. [The natural mutation encoding a C terminus-truncated 5-hydroxytryptamine 2B receptor is a gain of proliferative functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
13. [The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
14. [Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
15. [Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
16. [Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
17. [Identification of a key amino acid of the human 5-HT(2B) serotonin receptor important for sarpogrelate binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
18. [The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
20. [Expression of serotonin receptors 2B and 4 in human prostate cancer tissue and effects of their antagonists on prostate cancer cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
21. [Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
22. [Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
23. [Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
24. [Functional evidence for a 5‐HT2B receptor mediating contraction of longitudinal muscle in human small intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
25. [5-HT1D and 5-HT2B receptors mediate contraction of smooth muscle in human small intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
26. [5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
27. [Characterization of the 5-HT2b receptor in evaluation of aequorin detection of calcium mobilization for miniaturized GPCR high-throughput screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
28. [A population-specific HTR2B stop codon predisposes to severe impulsivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
29. [Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
30. [Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
31. [Serotonin promotes tumor growth in human hepatocellular cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
32. [Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41595&geneProductId=UniProtKB:P41595)
33. [Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41595)
34. Ensembl Release 99
35. Transporter Classification database