# 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex

> protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate

**Wikidata**: [Q22327132](https://www.wikidata.org/wiki/Q22327132)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Branched-chain_alpha-keto_acid_dehydrogenase_complex)  
**Source**: https://4ort.xyz/entity/3-methyl-2-oxobutanoate-dehydrogenase-lipoamide-complex


## References

1. Gene Ontology release 2019-10-07
2. Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease
3. Gene Ontology release 2022-07-01
4. UMLS 2023
5. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)