# 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

> mammalian protein found in Mus musculus

**Wikidata**: [Q14864142](https://www.wikidata.org/wiki/Q14864142)  
**Source**: https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-q14864142


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q01237)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237)
7. [Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237)
8. [Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237)
9. [Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237)
10. [Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237)
11. [Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237)
12. [Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237)
13. [ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237)
14. [Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237)
15. [Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01237&geneProductId=UniProtKB:Q01237)
16. [Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
17. [Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
18. [ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
19. [Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
20. [Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
21. [Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
22. [Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
23. [Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
24. [Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
26. [Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
27. [Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01237)
28. ensembl Release 106