# 3-hydroxy-3-methylglutaryl-CoA reductase

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562064](https://www.wikidata.org/wiki/Q28562064)  
**Source**: https://4ort.xyz/entity/3-hydroxy-3-methylglutaryl-coa-reductase-q28562064


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P51639)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
6. [Functional size of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by radiation inactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
7. [Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
8. [Contribution of increased HMG-CoA reductase gene expression to hypercholesterolemia in experimental chronic renal failure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
9. [Rat HMGCoA reductase activation in thioacetamide-induced liver injury is related to an increased reactive oxygen species content](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
10. [Influence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ubiquinone levels in rat skeletal muscle and heart: relationship to cytotoxicity and inhibitory activity for cholesterol synthesis in human skeletal muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
11. [Expression of cholesterol homeostasis genes in the brain of the male rat is affected by age and dietary restriction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
12. [Mechanisms underlying the impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in aged rat liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
13. [A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
14. [Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
15. [Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
16. [Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
17. [Synergistic action of statins and nitrogen-containing bisphosphonates in the development of rhabdomyolysis in L6 rat skeletal myoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
18. [Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
19. [Effects of statin treatment and withdrawal on angiotensin II-induced phosphorylation of p38 MAPK and ERK1/2 in cultured vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
20. [Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
21. [Mechanism underlying long-term regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase during L6 myoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
22. [Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
23. [3-hydroxy 3-methylglutaryl coenzyme A reductase increase is essential for rat muscle differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
24. [Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
25. [Simvastatin improves wound strength after intestinal anastomosis in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
26. [The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51639)
27. ensembl Release 104