{"schema_version":"4ort.packet/1","entity":{"entity_id":"hereditary-spastic-paraplegia-15","kg_uuid":"c9f5aec0-e907-4cb0-b881-18a2851321d7","wikidata_id":"Q32142628","name":"hereditary spastic paraplegia 15","description":"hereditary spastic paraplegia that has material basis in mutation in the ZFYVE26 gene on chromosome 14q24.1","type":"MedicalCondition","url":"https://4ort.xyz/entity/hereditary-spastic-paraplegia-15"},"status":"complete","as_of":{"copy_written_at":"2026-11-01T14:55:55Z","last_source_edit_seen":"2026-10-23T23:17:49Z","stale_possible":true,"claims_refreshed_at":null,"source_revision":null},"facts":[{"field":"P31","label":"instance of","value":"rare disease","value_id":"Q929833","value_raw":"Q929833","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P31","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[]},"trust":{"band":"unscored","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P31","label":"instance of","value":"class of disease","value_id":"Q112193867","value_raw":"Q112193867","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P31","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[]},"trust":{"band":"unscored","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P279","label":"subclass of","value":"autosomal recessive complex spastic paraplegia","value_id":"Q55345926","value_raw":"Q55345926","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P279","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"stated_in":"Monarch Disease Ontology release 2018-06-29","stated_in_id":"Q55345445","retrieved":"2018-07-03"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P486","label":"MeSH descriptor ID","value":"C536642","value_id":null,"value_raw":"C536642","rank":"normal","current":null,"qualifiers":[{"field":"P4390","label":"mapping relation type","value":"exact match"}],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P486","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"stated_in":"Monarch Disease Ontology release 2018-06-29","stated_in_id":"Q55345445","retrieved":"2018-07-03"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P492","label":"OMIM ID","value":"270700","value_id":null,"value_raw":"270700","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P492","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"stated_in":"Disease Ontology","stated_in_id":"Q5282129","retrieved":"2019-08-28"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P699","label":"Disease Ontology ID","value":"DOID:0110768","value_id":null,"value_raw":"DOID:0110768","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P699","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"stated_in":"Disease Ontology","stated_in_id":"Q5282129","retrieved":"2020-11-30"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P1193","label":"prevalence","value":"1e-06","value_id":null,"value_raw":{"amount":"+0.000001"},"rank":"normal","current":null,"qualifiers":[{"field":"P2312","label":"maximum value","value":"1e-06"}],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P1193","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"retrieved":"2026-10-23"}]},"trust":{"band":"medium","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P1550","label":"Orphanet ID","value":"100996","value_id":null,"value_raw":"100996","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P1550","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"stated_in":"Disease Ontology","stated_in_id":"Q5282129","retrieved":"2019-08-28"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P1995","label":"health specialty","value":"neurology","value_id":"Q83042","value_raw":"Q83042","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P1995","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[]},"trust":{"band":"unscored","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P2293","label":"genetic association","value":"ZFYVE26","value_id":"Q18037219","value_raw":"Q18037219","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P2293","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"url":"https://platform.opentargets.org/evidence/ENSG00000072121/MONDO_0010044","stated_in":"Open Targets Platform","stated_in_id":"Q113138000","retrieved":"2023-08-24"},{"url":"https://platform.opentargets.org/evidence/ENSG00000072121/Orphanet_100996","stated_in":"Open Targets Platform","stated_in_id":"Q113138000","retrieved":"2023-08-24"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P2841","label":"age of onset","value":"juvenile onset","value_id":"Q21955202","value_raw":"Q21955202","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P2841","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"retrieved":"2026-10-23"}]},"trust":{"band":"medium","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P2841","label":"age of onset","value":"adult onset","value_id":"Q21955204","value_raw":"Q21955204","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P2841","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"retrieved":"2026-10-23"}]},"trust":{"band":"medium","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P2841","label":"age of onset","value":"childhood onset","value_id":"Q21955201","value_raw":"Q21955201","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P2841","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"retrieved":"2026-10-23"}]},"trust":{"band":"medium","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P2888","label":"exact match","value":"http://purl.obolibrary.org/obo/DOID_0110768","value_id":null,"value_raw":"http://purl.obolibrary.org/obo/DOID_0110768","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P2888","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"stated_in":"Disease Ontology","stated_in_id":"Q5282129","retrieved":"2020-11-30"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P2888","label":"exact match","value":"http://identifiers.org/doid/DOID:0110768","value_id":null,"value_raw":"http://identifiers.org/doid/DOID:0110768","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P2888","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"url":"https://registry.identifiers.org/registry/doid","stated_in":"Identifiers.org","stated_in_id":"Q16335166"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P2888","label":"exact match","value":"http://www.orpha.net/ORDO/Orphanet_100996","value_id":null,"value_raw":"http://www.orpha.net/ORDO/Orphanet_100996","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P2888","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[]},"trust":{"band":"unscored","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P2892","label":"UMLS CUI","value":"C1849128","value_id":null,"value_raw":"C1849128","rank":"normal","current":null,"qualifiers":[{"field":"P4390","label":"mapping relation type","value":"exact match"}],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P2892","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"stated_in":"Monarch Disease Ontology release 2018-06-29","stated_in_id":"Q55345445","retrieved":"2018-07-03"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P4229","label":"ICD-10-CM","value":"G11.4","value_id":null,"value_raw":"G11.4","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P4229","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"stated_in":"Disease Ontology","stated_in_id":"Q5282129","retrieved":"2019-08-28"},{"stated_in":"Monarch Disease Ontology release 2018-06-29","stated_in_id":"Q55345445","retrieved":"2018-07-03"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P4317","label":"GARD rare disease ID","value":"9581","value_id":null,"value_raw":"9581","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P4317","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"stated_in":"Disease Ontology","stated_in_id":"Q5282129","retrieved":"2019-08-28"}]},"trust":{"band":"high","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P5270","label":"Mondo ID","value":"MONDO_0010044","value_id":null,"value_raw":"MONDO_0010044","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P5270","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[]},"trust":{"band":"unscored","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P6532","label":"has phenotype","value":"spasticity","value_id":"Q117060","value_raw":"Q117060","rank":"normal","current":null,"qualifiers":[{"field":"P1193","label":"prevalence","value":"0.55"}],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P6532","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"retrieved":"2026-10-23"}]},"trust":{"band":"medium","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P6532","label":"has phenotype","value":"gait abnormality","value_id":"Q827017","value_raw":"Q827017","rank":"normal","current":null,"qualifiers":[{"field":"P1193","label":"prevalence","value":"0.55"}],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P6532","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"retrieved":"2026-10-23"}]},"trust":{"band":"medium","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P6532","label":"has phenotype","value":"muscle weakness","value_id":"Q270421","value_raw":"Q270421","rank":"normal","current":null,"qualifiers":[{"field":"P1193","label":"prevalence","value":"0.55"}],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P6532","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"retrieved":"2026-10-23"}]},"trust":{"band":"medium","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P6532","label":"has phenotype","value":"basal ganglia disease","value_id":"Q4866181","value_raw":"Q4866181","rank":"normal","current":null,"qualifiers":[{"field":"P1193","label":"prevalence","value":"0.55"}],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P6532","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"retrieved":"2026-10-23"}]},"trust":{"band":"medium","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P6532","label":"has phenotype","value":"Lower limb hyperreflexia","value_id":"Q141815173","value_raw":"Q141815173","rank":"normal","current":null,"qualifiers":[{"field":"P1193","label":"prevalence","value":"0.55"}],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P6532","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[{"retrieved":"2026-10-23"}]},"trust":{"band":"medium","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P11430","label":"UniProt disease ID","value":"DI-01046","value_id":null,"value_raw":"DI-01046","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P11430","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[]},"trust":{"band":"unscored","basis":"wikidata-reference-support/2","calibrated":false}},{"field":"P14914","label":"P14914","value":"D100996","value_id":null,"value_raw":"D100996","rank":"normal","current":null,"qualifiers":[],"layer":"source","citation":{"source":"wikidata","source_name":"Wikidata","source_record":"https://www.wikidata.org/wiki/Q32142628#P14914","source_edition":null,"edition_basis":"unknown","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"references":[]},"trust":{"band":"unscored","basis":"wikidata-reference-support/2","calibrated":false}}],"unknowns":[],"omitted":{"facts":0,"reason":null},"licences":[{"source":"wikidata","source_name":"Wikidata","licence":"CC0 1.0 Universal","licence_url":"https://creativecommons.org/publicdomain/zero/1.0/","attribution":null,"fields":["P31","P279","P486","P492","P699","P1193","P1550","P1995","P2293","P2841","P2888","P2892","P4229","P4317","P5270","P6532","P11430","P14914"]}],"routes":{"entity_page":"https://4ort.xyz/entity/hereditary-spastic-paraplegia-15","packet_api":"https://4ort.xyz/api/v1/entities/hereditary-spastic-paraplegia-15/packet","facts_jsonld":"https://4ort.xyz/entity/hereditary-spastic-paraplegia-15/facts.json","changes_api":"https://4ort.xyz/api/v1/knowledge/get_entity_changes?entity=hereditary-spastic-paraplegia-15","attention_api":"https://4ort.xyz/api/v1/knowledge/get_attention?entity=hereditary-spastic-paraplegia-15","wikidata":"https://www.wikidata.org/wiki/Q32142628","official_website":null},"trust_rules":{"wikidata-reference-support/2":"From the references in our copy of the statement: high = it cites a source (stated in P248, or a reference URL that is not Wikipedia); medium = only 'imported from Wikimedia project' or a Wikipedia URL; unscored = our copy holds no reference (older copies dropped references, so this is not evidence that Wikidata has none). Wikidata may hold more references than our copy shows. Reference support, not a probability."},"notes":["Our copy of this item's statements has not been checked against Wikidata since tracking began (2026-10-25); a newer value may exist."]}